Isis Ishtar (called "Ishizu Ishtar" in the dub animation, which is pronounced Ee-shee-zoo, rather than the Japanese pronunciation of the Egyptian name, Eye-shee-zoo, for Isis/Eye-sis) is the oldest daughter of one branch of the Tombkeeper clan (the one that guarded the tablets and the Millennium Rod and Millennium Torque), and unlike previous members from her clan, she holds a position within the Egyptian government as the Secretary General on the Supreme Council of Antiquities (while Isis the character is fictional, the organization and her position are not). The dub changed this title to "Director of the Egyptian Bureau of Archeology", but the Viz manga retains it.
Isis witnessed her brother Malik's descent into madness after he, as the oldest natural-born male of the Tombkeeper family, was forced to undergo a ritual that involved carving hieroglyphics of the Pharaoh's Memory into his back. After her brother decided to steal the Egyptian God Cards in an effort to defeat the Pharaoh whom Shaadii had said "willed" the death of the Ishtar patriarch, Isis took over as family head. She protected the location of the only God Card Malik had not stolen, that of Obelisk the Tormentor. She later traveled to Japan with an exhibition of artifacts from the period that her family sought to protect, and met with Seto Kaiba. She bestowed the Obelisk the Tormentor card on him, on the condition that he would use it to lure out Malik's newly-formed gang of card thieves, calling themselves the Ghouls (Rare Hunters in the dub anime). She also said he would give it back to her, though Kaiba didn't believe her, nor in her powers from the Millennium Torque.
She predicted the defeat of Seto Kaiba in the semi-finals during Battle City, but a vision Kaiba had (possibly due to the influence of the Millennium Rod) altered the future she had seen, allowing Kaiba to emerge victorious from their duel.
Birthday: April 5th, 1975 (Aries), 20 years old at first appearance
Height: 167 cm (approximately 5'5")
Weight: 43 kg (approximately 94.8 lbs.)
Hair Color: Black
Eye Color: Blue
Blood Type: O
Favorite Food: Om ali (an Egyptian dessert consisting of puffed pastry, milk, and nuts)
Least Favorite Food: Foods with meat
Signature Duel Monsters Card(s): Exchange of the Spirit
Deck Theme: Light/Fairy/Spellcaster